Genome-Wide Analysis of Sheep Artificially or Naturally Infected with Gastrointestinal Nematodes

The anthelmintic resistance of gastrointestinal nematodes (GINs) poses a significant threat to sheep worldwide, but genomic selection can serve as an alternative the use chemical treatment solution for parasitic infection. objective this study is conduct genome-wide association studies (GWASs) identify single nucleotide polymorphisms (SNPs) in Rambouillet (RA) and Dorper × White (DWD) lambs associated with biological response GIN All were genotyped medium-density panel 40,598 markers used analysis. Separate GWASs conducted using fecal egg counts (FECs) from (<1 year age) that acquired their artificial infections via oral inoculation 10,000 Haemonchus contortus larvae (n = 145) or naturally while grazing on pasture 184). A GWAS was also performed packed cell volume (PCV) artificially GIN-challenged lambs. total 26 SNPs exceeded significance 21 within 20 kb genes such SCUBE1, GALNT6, IGF1R, CAPZB PTK2B. ontology analysis candidate signifies importance immune development, mucin production cellular signaling coagulation wound healing following epithelial damage abomasal gastric pits H. during infection These results add growing body literature promotes increased GINs.